{"id":9836,"date":"2025-08-18T15:48:15","date_gmt":"2025-08-18T15:48:15","guid":{"rendered":"http:\/\/drmhasghari.com\/inhibition-of-mek-erk-signalling-pathway-promotes-erythroid-differentiation-and-reduces-hscs-engraftment-in-ex-vivo-expanded-haematopoietic-stem-cells\/"},"modified":"2025-09-12T17:59:52","modified_gmt":"2025-09-12T17:59:52","slug":"inhibition-of-mek-erk-signalling-pathway-promotes-erythroid-differentiation-and-reduces-hscs-engraftment-in-ex-vivo-expanded-haematopoietic-stem-cells","status":"publish","type":"post","link":"https:\/\/drmhasghari.com\/en\/inhibition-of-mek-erk-signalling-pathway-promotes-erythroid-differentiation-and-reduces-hscs-engraftment-in-ex-vivo-expanded-haematopoietic-stem-cells\/","title":{"rendered":"Inhibition of the MEK\/ERK Signaling Pathway Enhances Erythroid Differentiation but Reduces the Engraftment Potential of Ex Vivo Expanded Hematopoietic Stem Cells"},"content":{"rendered":"

[vc_row][vc_column][vc_empty_space][vc_column_text css=””]<\/p>\n

Recent studies have demonstrated that the MEK\/ERK<\/strong> signaling pathway is one of the key regulators of cell growth, survival, and differentiation. But the crucial question is: what role does this pathway play in \u201cself-renewal,\u201d or the ability of hematopoietic stem cells to regenerate? <\/p>\n

In this study, human umbilical cord blood stem cells were examined under laboratory conditions. When the activity of the MEK\/ERK pathway was blocked with a specific inhibitor, the proliferation of stem cells decreased, although their stemness characteristics (such as the genes HOXB\u06f4 and BMI\u06f1) were preserved. However, their ability to engraft in vivo was reduced. <\/p>\n

On the other hand, the results showed that inhibiting this pathway naturally directed the cells toward erythroid differentiation<\/strong> (the production of red blood cells). The number of new blood colonies increased, and genes promoting blood differentiation (such as TAL\u06f1 and GATA\u06f2) became more active, while inhibitory genes (such as JUN and PU\u06f1) decreased. <\/p>\n

In summary, this study demonstrates that the MEK\/ERK pathway maintains a delicate balance between proliferation and differentiation of umbilical cord blood stem cells. Moreover, inhibition of this pathway could offer a novel approach for generating red blood cells in regenerative medicine and in the treatment of hematological diseases. <\/p>\n

\n

Link: Inhibition of MEK\/ERK signalling pathway promotes erythroid differentiation and reduces HSCs engraftment in ex vivo expanded haematopoietic stem cells<\/a><\/strong><\/p>\n<\/blockquote>\n

[\/vc_column_text][vc_empty_space][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"

Examining the role of the MEK\/ERK pathway in umbilical cord blood stem cells shows that inhibiting this pathway reduces cell proliferation while enhancing their differentiation into red blood cells\u2014an important finding for regenerative medicine and the treatment of blood disorders.<\/p>\n","protected":false},"author":2,"featured_media":9646,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[82],"tags":[],"class_list":["post-9836","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-scientific-articles"],"_links":{"self":[{"href":"https:\/\/drmhasghari.com\/en\/wp-json\/wp\/v2\/posts\/9836","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/drmhasghari.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/drmhasghari.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/drmhasghari.com\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/drmhasghari.com\/en\/wp-json\/wp\/v2\/comments?post=9836"}],"version-history":[{"count":5,"href":"https:\/\/drmhasghari.com\/en\/wp-json\/wp\/v2\/posts\/9836\/revisions"}],"predecessor-version":[{"id":9845,"href":"https:\/\/drmhasghari.com\/en\/wp-json\/wp\/v2\/posts\/9836\/revisions\/9845"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/drmhasghari.com\/en\/wp-json\/wp\/v2\/media\/9646"}],"wp:attachment":[{"href":"https:\/\/drmhasghari.com\/en\/wp-json\/wp\/v2\/media?parent=9836"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/drmhasghari.com\/en\/wp-json\/wp\/v2\/categories?post=9836"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/drmhasghari.com\/en\/wp-json\/wp\/v2\/tags?post=9836"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}